Allelic Loss on Chromosome Arm 8p: Analysis of Sporadic Epithelial Ovarian Tumors
β Scribed by Monica R. Brown; Rodrigo Chuaqui; Cathy D. Vocke; Andrew Berchuck; Lavinia P. Middleton; Michael R. Emmert-Buck; Elise C. Kohn
- Book ID
- 112247764
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 142 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0090-8258
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A previous study of 18 primary or metastatic prostate cancers showed loss of genetic markers on chromosome 8; 10, or 16 in more than 50% of cases [Bergerheim USR et al. (1991) Genes Chromosom Cancer 3:215β220]. The small size and infiltrative nature of primary prostatic tumors have hind
Genetic changes have been shown to be important in determining the multistep progression of cancer. Allele loss studies and karyotypic analysis of epithelial ovarian tumours have indicated the presence of putative w m u r suppressor genes on chromosomes 6, I I, I 3, 17, I8,22, and X. We have focused
Breast-carcinoma development presumably results from multiple mutational events in tumor-associated genes. Certain results indicate that some tumor-suppressor genes may combine their pathogenetic potential to synergistically promote tumor growth. In an effort to identify such mechanisms in breast tu