## Abstract A previous study of 18 primary or metastatic prostate cancers showed loss of genetic markers on chromosome 8; 10, or 16 in more than 50% of cases [Bergerheim USR et al. (1991) Genes Chromosom Cancer 3:215โ220]. The small size and infiltrative nature of primary prostatic tumors have hind
High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma
โ Scribed by Ingrid Pribill; Paul Speiser; Jennifer Leary; Sepp Leodolter; Neville F Hacker; Michael L Friedlander; Daniel Birnbaum; Robert Zeillinger; Michael Krainer
- Book ID
- 114135091
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 979 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Loss of chromosome arm 8p, sometimes in combination with amplification of proximal 8p, is found in urothelial carcinoma (UC) and other epithelial cancers and is associated with more advanced tumor stage. We carried out array comparative genomic hybridization on 174 UC and 33 UC cell lin
Deletions on chromosome arm 8p, as defined by allelic imbalance, are a frequent event in many different types of malignant tumors, including those of the head and neck. These regions are thought to harbor tumor suppressor genes. In order to define a high-density deletion map of this chromosomal arm