Allelic losses on chromosome arm 22q are frequently observed in human meningiomas and in carcinomas of the colon, ovary, and breast. Among 140 primary breast cancers we examined for loss of heterozygosity (LOH) at 16 polymorphic loci on the long arm of chromosome 22, 56 (40%) showed LOH for at least
Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17
β Scribed by Yuan-Chang Dai; Chung-Liang Ho; Yi-Chang Tsai; Yung-Hsiang Hsu; Yu-Chuang Chang; Hsiao-Sheng Liu; Helen Hai-Wen Chen; Nan-Haw Chow
- Book ID
- 106123416
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 416 KB
- Volume
- 131
- Category
- Article
- ISSN
- 1432-1335
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A detailed analysis of loss of heterozygosity (LOH) in breast cancers was performed with 11 microsatellite markers on the long arm of chromosome 21. Among the 142 tumors examined, 44 (31%) showed LOH at one or more loci. Peak LOH frequency was observed on band 21q21. Deletion mapping identified a ne
## Abstract Despite the abundant evidence of high allelic loss of chromosome arm 14q in human cancers, tumorβsuppressor genes mapped to this chromosome have yet to be identified. To narrow the search for candidate genes, we performed monochromosome transfer of chromosome 14 into an esophageal carci