✦ LIBER ✦

Allelic loss in ovarian cancer

✍ Scribed by Teresa L. Yang-Feng; Hong Han; Kuang-Chao Chen; Shi-Bo Li; Elizabeth B. Claus; Maria L. Carcangiu; Setsuko K. Chambers; Joseph T. Chambers; Peter E. Schwartz

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 618 KB
Volume: 54
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910540405

No coin nor oath required. For personal study only.

✦ Synopsis

Loss of heterozygosity (LOH) was examined at 86 loci distributed on every chromosomal arm in 50 human ovarian tumors. Frequent allele losses were observed on chromosomes 13q (42%), I7p (42%), 17q YO), and X p (4 I Yo). Deletion mapping on chromosome I 7 revealed a candidate gene on the long arm distal to D17S41 /S74 for ovarian cancer which is distant from the locus for early onset breast cancer. LOH on chromosome 17q was found to be concordant with LOH on chromosomes 3p, 13q, 17p and Xp suggesting that it may be an early event in neoplastic development. These findings indicate that multiple tumor-suppressor genes for ovarian cancer possibly exist on chromosomes 13q. 17, and/or Xp and provide the basis for the identification of candidate gene@) associated with ovarian cancer. The chromosomal mechanisms resulting in allele losses in ovarian cancer include deletion, deletion/duplication, mitotic recombination and monosomy, in concordance with the developed genetic model.

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