Allelic imbalance of HER2 variant in sporadic breast and ovarian cancer
β Scribed by Marjut Puputti; Harri Sihto; Jorma Isola; Ralf Butzow; Heikki Joensuu; Nina N. Nupponen
- Book ID
- 113512603
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 241 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0165-4608
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The PTEN/MMAC1/TEP1 tumor-suppressor gene, which maps to chromosome 10q23.3, is mutated and homozygously deleted in a variety of human tumors, including endometrioidtype ovarian tumors. We examined 33 primary ovarian cancers and 3 ovarian borderline tumors for allelic imbalance (AI) of the 10q23.3 r
## Abstract Recent genomeβwide scans identified several novel breast cancer risk alleles, including variants of the __FGFR2__, __MAP3K1__ and __LSP1__ genes, and a study of associations between these alleles and characteristics of breast cancer patients reported a borderline significant correlation