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Allele Loss on Chromosome 11 in a Pituitary Tumor from a Patient with Multiple Endocrine Neoplasia Type 1

✍ Scribed by Yoshimoto, Katsuhiko ;Iwahana, Hiroyuki ;Kubo, Katsuyuki ;Saito, Shiro ;Itakura, Mitsuo


Book ID
108579356
Publisher
Wiley (Blackwell Publishing)
Year
1991
Tongue
English
Weight
236 KB
Volume
82
Category
Article
ISSN
0910-5050

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The gene responsible for multiple endocrine neoplasia type I (MEN-l) syndrome has been mapped to chromosome l lq13. It appears to function as a tumoursuppressor gene analogous to that for retinoblastoma and allelic losses involving the wild-type of the MEN-1 allele have been found in parathyroid and