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Allele frequencies and linkage disequilibrium of polymorphic DNA markers of the Huntington disease region in the German population

✍ Scribed by Ulrike Thies; Barbara Bockel; Barbara Gerdes; Kirsten Schröder

Publisher
Springer
Year
1993
Tongue
English
Weight
417 KB
Volume
92
Category
Article
ISSN
0340-6717

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✦ Synopsis

Allele frequencies of 14 different restriction fragment length polymorphisms from 12 DNA markers within the Huntington disease (HD) region were evaluated in the German population. No significant differences from published data of allele frequencies from chromosomes of Caucasian ancestry were found. The analysis of eight DNA polymorphisms in 87 HD families of German origin revealed significant non-random association with the HD locus and the D4S95 locus (p674/AccI/MboI), a result that is consistent with all other published studies. These results are confirmed by the fact that the HD gene maps to this region.

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