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All-trans retinoid acid increases Notch1 transcript expression in acute promyelocytic leukemia

✍ Scribed by Jen-Tsun Lin; Ming-Shiuan Wu; Wei-Shu Wang; Chueh-Chuan Yen; Tzeon-Jye Chiou; Jin-Hwang Liu; Mu-Hua Yang; Ta-Chon Chao; Shu-Chaou Chou; Po-Min Chen

Book ID
105633400
Publisher
Springer Healthcare Communications
Year
2003
Tongue
English
Weight
122 KB
Volume
20
Category
Article
ISSN
0741-238X

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## Abstract ## Background Due to severe side effects in virtually all children treated with a standard dose of 45 mg/m^2^/day all‐__trans__‐retinoic acid (ATRA) for acute promyelocytic leukemia (APL) the AML‐BFM study group reduced the dosage to 25 mg/m^2^/day. For the lack of data on the use of A