Alkylation of Enolates
β Scribed by David L. Hughes
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 7 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Tris(dialkylamino)sulfonium enolates generated from tris(diethylamino)sulfonium difluorotrimethylsiliconate and enol silyl ethers are readily alkylated by various alkyl halides under mild conditions. Recently we have demonstrated that reaction of tris(diethylamino)sulfonium (TAS) difluorotrimethylsi
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## Abstract Palladiumβcatalyzed asymmetric allylic alkylation of nonstabilized ketone enolates to generate quaternary centers has been achieved in excellent yield and enantioselectivity. Optimized conditions consist of performing the reaction in the presence of two equivalents of LDA as base, one e