𝔖 Bobbio Scriptorium
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Alkylation of carbanions from isoxazolin-5-ones

✍ Scribed by Samuel A. Tischler; Larry Weiler

Book ID
104238080
Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
190 KB
Volume
20
Category
Article
ISSN
0040-4039

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✦ Synopsis

Methyl acetoacetate and other B-keto esters can be converted into the corresponding isoxazolin-5-ones which can be metalated a to C-3. These anions are trapped by a range of electrophiles to produce 3-substituted isoxazolin-5-ones. Recently we required various B-amino a,B-unsaturated esters as

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