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Alkylation mutagenesis inSaccharomyces cerevisiae:lack of evidence for an adaptive response

✍ Scribed by Renata Polakowska; Giuditta Perozzi; Louise Prakash

Publisher: Springer-Verlag
Year: 1986
Tongue: English
Weight: 678 KB
Volume: 10
Category: Article
ISSN: 0172-8083
DOI: 10.1007/bf00410912

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✦ Synopsis

We have found no evidence for an adaptive response for either lethality or mutagenesis following treatment of Saccharomyces cerevisiae with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The rad6 and rad52 mutants of S. cerevisiae are highly defective in MNNG and ethyl methanesulfonate induced mutagenesis of both stationary and exponential phase cells. These and other observations indicate that the mechanisms of repair of alkylation damage and mutagenesis differ markedly between S. cerevisiae and Escherichia coli.

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