Alkylated chitosans of low molecular weight as non-viral transfection vectors for gene therapy
✍ Scribed by Xin Zhang; S. Ercelen; V. E. Tikhonov; S. Z. Karaeva; A. V. Slita; V. V. Zarubaev; Y. Mély; G. Duportail; V. G. Babak
- Book ID
- 111459680
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 261 KB
- Volume
- 78
- Category
- Article
- ISSN
- 1070-3632
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## Abstract Poly(L‐succinimide)‐__graft__‐polyethylenimines (PSPs) were prepared as non‐viral vectors for gene transfection. Branched polyethylenimine ($\overline M \_{\rm w} $ = 800, PEI800) was grafted to poly(L‐succinimide) (PSI) in a one‐step reaction with no catalyst. Gel retardation assay sho
A novel class of non-viral gene vectors consisting of low molecular weight poly(ethylene imine) (PEI) (molecular weight 800 Da) grafted onto degradable linear poly(ethylene glycol) (PEG) analogs was synthesized. First, a Michael addition reaction between poly(ethylene glycol) diacrylates (PEGDA) (mo