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Alkaloid Production in Catharanthusroseus Cell Cultures. IV. Characterization of the 953 Cell Line

✍ Scribed by Wolfgang G. W. Kurz; Kenneth B. Chatson; Friedrich Constabel; James P. Kutney; Lewis S. L. Choi; Pawel Kolodziejczyk; Stephen K. Sleigh; Kenneth L. Stuart; Brian R. Worth

Publisher
John Wiley and Sons
Year
1980
Tongue
German
Weight
309 KB
Volume
63
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The 953 cell line, one of the cell lines from Catharanthus roseus, has been investigated in terms of its ability to produce indole alkaloids. Various parameters (mitotic index, pH, cell dry weight, growth period) were evaluated in the fermentation process and their relative importance for alkaloid production was determined. The alkaloids isolated and identified are ajmalicine, yohimbine, isositsirikine, vallesiachotamine, strictosidine lactam, lochnericine, hörhammericine, hörhammerinine, vindolinine, 19‐epivindolinine, 19‐acetoxy‐11‐methoxytabersonine, 19‐hydroxy‐11‐methoxytabersonine and dimethyltryptamine.

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