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Alkaloid Production in Catharanthus roseus Cell Cultures X. Mitotoxic Effect of 3′,4′-Dehydrovinblastine

✍ Scribed by Constabel, F.; Rambold, S.; Shyluk, J.P.; LeTourneau, D.; Kurz, W.G.W.; Kutney, J.P.

Book ID
122233687
Publisher
Elsevier
Year
1981
Weight
303 KB
Volume
105
Category
Article
ISSN
0044-328X

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## Abstract Biotransformation studies of 3′,4′‐anhydrovinblastine **(1)** in __Calharanthus roseus__ cell suspension cultures are reported. A detailed study of one cell line, coded at „916”︁, has revealed that **1** is transformed to the natural bisindole alkaloids leurosine (**2**) and Catharine (