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Alkaloid catalysed asymmetric synthesis. The addition of selenophenols to 2-cyclohexen-1-ones and conversion to optically active allylic alcohols

✍ Scribed by Henk Pluim; Hans Wynberg

Publisher: Elsevier Science
Year: 1979
Tongue: French
Weight: 211 KB
Volume: 20
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)86116-5

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✦ Synopsis

The cinchona alkaloid catalyzed 1,Caddltlon reaction of selenophenols to cyclohexenols has been shown to proceed with asyannetric lnductlon. Optically active selenium adducts are formed in quantitative chemical and up to 43% enanticmeric yields. The transformation to an optically active chiral ally1 alcohol is described.

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