✦ LIBER ✦
Alkaloid catalyzed asymmetric synthesis III the addition of mercaptans to 2-cyclohexene-1-one; determination of enantiomeric excess using 13C NMR.
✍ Scribed by R. Helder; R. Arends; W. Bolt; H. Hiemstra; Hans Wynberg
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- French
- Weight
- 117 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The addition of mercaptans to a,B-unsaturated systems is an important reaction in biosynthetic processes2 as well as in synthesis.3 We wish to report the formation in excellent yields of a series of B-ketosulfides in enantiomeric excess up to 50% by the addition of mercaptans to 2-cyclohexene-l-one in the presence of catalytic quantities of quinine.4 R--SH