Alkali metal hydride or aqueous hydroxide induced conjugate addition of trimethylsilyl enol ethers to enones. A convenient alternative to Lewis acid mediated reaction

✍ Scribed by Vishwanath M. Swamy; Amitabha Sarkar

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 152 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)10771-7

✦ Synopsis

Conjugate addition to enones by enolates derived from baseqnduced cleavage of O-Si bond of trimethylsilyl enol ethers, yields 1,5-dicarbonyl compounds in good yields.