Aliphatic organolithiums by fluorine–lit
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Miguel Yus; Raquel P Herrera; Albert Guijarro
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Article
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2003
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Elsevier Science
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French
⚖ 72 KB
The reaction of 1-fluorooctane (1) with an excess of lithium powder (4-10 equiv.) and DTBB (2-4 equiv.) in THP at 0°C for 5 min gives a solution of the corresponding 1-octyllithium (2), which reacts then with different electrophiles at 0°C (D 2 O, MeSiCl, Bu t CHO, Et 2 CO), or -78°C [ClCO 2 Me, (Ph