Alginate microparticles for enzyme peroral administration
β Scribed by G Coppi; V Iannuccelli; M.T Bernabei; R Cameroni
- Book ID
- 108454104
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 149 KB
- Volume
- 242
- Category
- Article
- ISSN
- 0378-5173
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## Abstract Alginate microparticles produced by emulsification/internal gelation were investigated as a promising carrier for insulin delivery. The procedure involves the dispersion of alginate solution containing insulin protein, into a water immiscible phase. Gelation is triggered in situ by inst
Propylene glycol alginate forms strong, covalently bonded gel when mixed with certain proteins in alkaline conditions. Enzymes can be immobilised onto the alginate ester before gelating with protein to form the above gel. Some data on the immobilisation of 8glucosidase are presented.