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Aldosterone Antagonists. 1. Synthesis and Activities of 6β,7β:15β,16β-Dimethylene Steroidal Spirolactones

✍ Scribed by Nickisch, Klaus; Bittler, Dieter; Casals-stenzel, Jorge; Laurent, Henry; Nickolson, Robert; Nishino, Yukishige; Petzoldt, Karl; Wiechert, Rudolf


Book ID
126324171
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
675 KB
Volume
28
Category
Article
ISSN
0022-2623

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Synthesis of (25R)-5α- 6β,15α,16β, a Cytostatic Starfish Steroid. -The title steroid (VII) is synthesized from diosgenin (I). The key step is the oxidation of the enolsilane (IV) with dimethyldioxirane to introduce the 15α-hydroxy group. -(IZZO, I.; DE