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Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: Possible involvement of mitochondrial S-adenosylmethionine transport

โœ Scribed by Zhenyuan Song; Zhanxiang Zhou; Ming Song; Silvia Uriarte; Theresa Chen; Ion Deaciuc; Craig J. McClain


Book ID
113488281
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
803 KB
Volume
74
Category
Article
ISSN
0006-2952

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S-adenosylhomocysteine sensitizes to TNF
โœ Zhenyuan Song; Zhanxiang Zhou; Silvia Uriarte; Lipeng Wang; Y. James Kang; There ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 999 KB

In alcoholic liver disease, tumor necrosis factor-a (TNFa) is a critical effector molecule, and abnormal methionine metabolism is a fundamental aquired metabolic abnormality. Although hepatocytes are resistant to TNFa-induced killing under normal circumstances, previous studies have shown that prima