In alcoholic liver disease, tumor necrosis factor-a (TNFa) is a critical effector molecule, and abnormal methionine metabolism is a fundamental aquired metabolic abnormality. Although hepatocytes are resistant to TNFa-induced killing under normal circumstances, previous studies have shown that prima
✦ LIBER ✦
S-adenosylhomocysteine sensitizes to TNF-α hepatotoxicity in mice and liver cells: A possible etiological factor in alcoholic liver disease
✍ Scribed by Zhenyuan Song; Zhanxiang Zhou; Silvia Uriarte; Lipeng Wang; Y. James Kang; Theresa Chen; Shirish Barve; Craig J. McClain
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 473 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0270-9139
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Hepatic stem cells are activated after liver damage and have a critical role in tissue homeostasis and repair. Characterization of molecular and cellular events accompanying the expansion and differentiation of liver stem cells is essential for understanding the basic biology of stem cells and for f