Alcohol and liver (IV)
β Scribed by Tanaka, K. ;Kawaguchi, Y. ;Kimura, A. ;Ohkawa, K. ;Nishikawa, H. ;Osamura, H. ;Okabe, K. ;Fujisawa, K. ;Takahashi, T.
- Publisher
- Springer-Verlag
- Year
- 1972
- Tongue
- English
- Weight
- 121 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0435-1339
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An increase of serum type IV collagen levels in patients with liver disease has been reported; however, the mechanisms of this increase are not yet well known. We recently developed an assay system for type IV collagen content in liver biopsy specimens. In this study, type IV collagen content in the
## **Acute and chronic ethanol treatment has been shown to increase the production of reactive oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many tissues, especially the liver. Ethanol-induced oxidative stress plays a major role in the mechanisms by which ethan