Albumin: Biochemical properties and therapeutic potential

✍ Scribed by Gregory J. Quinlan; Greg S. Martin; Timothy W. Evans

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 319 KB
• Volume: 41
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.20720

✦ Synopsis

Ligand-Binding. HSA binds many endogenous and exogenous compounds, including fatty acids, metal ions, pharmaceuticals, and metabolites, with implications for drug delivery and efficacy, detoxification, and antioxidant protection. Several low-and high-affinity ligand-binding sites have been identified on HSA, the first of which to be identified (termed site I and II) are responsible for the binding of most pharmaceuticals that interact with the protein. Sites I and II are located in different domains and Abbreviations: HSA, human serum albumin; NO, nitric oxide; ROS, reactive oxygen species; RNS, reactive nitrogen species; COP, colloid oncotic pressure.