Purinergic signalling: Therapeutic potential
✍ Scribed by Geoffrey Burnstock
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 105 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
✦ Synopsis
This article begins with a brief review of the current status of receptor subtypes for purines and pyrimidines. It then focuses on pathophysiological roles of ATP and discusses some related therapeutic possibilities. Finally, the expanding field of purinergic signalling in embryology is introduced.
📜 SIMILAR VOLUMES
## Abstract Adenosine 5′‐triphosphate (ATP) was identified in 1970 as the transmitter responsible for non‐adrenergic, non‐cholinergic neurotransmission in the gut and bladder and the term ‘purinergic’ was coined. Purinergic cotransmission was proposed in 1976 and ATP is now recognized as a cotransm
## Abstract Bone remodeling is a process of continuous resorption and formation/mineralization carried out by osteoclasts and osteoblasts, which, along with osteocytes, comprise the bone multicellular unit (BMU). A key component of the BMU is the bone remodeling compartment (BRC), isolated from the
## Abstract CD73/ecto‐5′‐nucleotidase dephosphorylates extracellular AMP into adenosine, and it is a key enzyme in the regulation of adenosinergic signaling. The contribution of host CD73 to tumor growth and anti‐tumor immunity has not been studied. Here, we show that under physiological conditions