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Aladan scanning: The structure-activity relationship of dynorphin A

✍ Scribed by HeRu Chen; Yang Yang; JiangDuo Weng

Book ID
107348762
Publisher
SP Science China Press
Year
2009
Tongue
English
Weight
650 KB
Volume
52
Category
Article
ISSN
1674-7291

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Following up on the observation that the dynorphin analog [Pro(3)]Dyn A(1-11)-NH(2) 2 possesses high affinity and selectivity for the kappa opioid receptor, a number of related peptides were prepared and characterized by radioligand binding and [(35)S]GTPgammaS assays. While incorporation of 2-azeti