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Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation

✍ Scribed by Hong-Sheng Zhang; Wei-Wei Sang; Zheng Ruan; Yu-Ou Wang

Book ID
116178759
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
602 KB
Volume
505
Category
Article
ISSN
0003-9861

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✍ Hong-Sheng Zhang; Zheng Ruan; Wei-Wei Sang 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB

Chromatin remodeling, especially in relation to the transactivator Tat, is an essential event for human immunodeficiency virus-1 (HIV-1) transcription. Curcumin has been shown to suppress pathways linked to HIV-1 replication. We investigated whether curcumin had the potential to inhibit Tat-induced