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Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

✍ Scribed by Chen, Juhua; Somanath, Payaningal R; Razorenova, Olga; Chen, William S; Hay, Nissim; Bornstein, Paul; Byzova, Tatiana V

Book ID: 109932765
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 717 KB
Volume: 11
Category: Article
ISSN: 1078-8956
DOI: 10.1038/nm1307

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## Abstract Maintaining homogeneous perfusion in tissues undergoing remodeling and vascular expansion requires tight orchestration of the signals leading to endothelial sprouting and subsequent recruitment of perivascular contractile cells and vascular maturation. This regulation, however, is frequ