## Abstract Human proximal tubule (HK‐2) cells are commonly used as cellular models to understand the mechanism by which inflammatory mediators cause renal injury. It has been observed that thrombin stimulates the expression of TGF‐β, extracellular matrix (ECM) proteins and proinflammatory cytokine
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-β activation
✍ Scribed by Crawford, Susan E; Mavroudis, Constantine D; Cornwell, Mona L; Doll, Jennifer A; Fitchev, Philip P; Wcislak, Susan M; Lee, Chung; Bergh, Anders; Brendler, Charles B; Stellmach, Veronica M
- Book ID
- 109885572
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 829 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0023-6837
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Ubiquitination of protein species in regulating signal transduction pathways is universally accepted as of fundamental importance for normal development, and defects in this process have been implicated in the progression of many human diseases. One pathway that has received much attent
## Abstract We investigated the effects of overexpression of the tuberous sclerosis‐1 and ‐2 (__TSC1/2__) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previously in fibroblasts, 293 cells over