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Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

✍ Scribed by Wang, R. C.; Wei, Y.; An, Z.; Zou, Z.; Xiao, G.; Bhagat, G.; White, M.; Reichelt, J.; Levine, B.

Book ID: 118139814
Publisher: American Association for the Advancement of Science
Year: 2012
Tongue: English
Weight: 772 KB
Volume: 338
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.1225967

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## Abstract Numerous studies have shown that mammalian target of rapamycin (mTOR) inhibitor activates Akt signaling pathway via a negative feedback loop while inhibiting mTORC1 signaling. In this report, we focused on studying the role of mTORC1 and mTORC2 in rapamycin‐mediated Akt and ERK phosphor