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Airways pharmacology of DNK333A, a dual NK1/NK2 neurokinin receptor antagonist

✍ Scribed by C A Lewis; K Hoshiko; H -J Pfannkuche; H Ball; N Subramanian; M Gerspacher; J R Fozard

Book ID
110007483
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
109 KB
Volume
137
Category
Article
ISSN
0007-1188

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✍ C.A. Lewis; A.Z. El-Hashim; M. Gerspacher; K. Hoshiko; L. Mazzoni; H.-J. Pfannku πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 309 KB

## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)‐N‐[3,4‐dichlorobenzyl)]‐4‐[(hexahydro‐2‐oxo‐1H‐azepin‐3‐yl)amino]‐N‐methyl‐3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high