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A potent and selective non-peptide antagonist of the neurokinin a (NK2) receptor

✍ Scribed by X. Emonds-Alt; P. Vilain; P. Goulaouic; V. Proietto; D. Van Broeck; C. Advenier; E. Naline; G. Neliat; G. Le Fur; J.C. Breliére


Book ID
118345538
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
359 KB
Volume
50
Category
Article
ISSN
0024-3205

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The airways pharmacology of DNK333, a po
✍ C.A. Lewis; A.Z. El-Hashim; M. Gerspacher; K. Hoshiko; L. Mazzoni; H.-J. Pfannku 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB

## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)‐N‐[3,4‐dichlorobenzyl)]‐4‐[(hexahydro‐2‐oxo‐1H‐azepin‐3‐yl)amino]‐N‐methyl‐3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high