Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs
✍ Scribed by Anne Lecklin; Ingrid Lundell; Suvi Salmela; Pekka T Männistö; Annette G Beck-Sickinger; Dan Larhammar
- Book ID
- 110007922
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 244 KB
- Volume
- 139
- Category
- Article
- ISSN
- 0007-1188
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The respective distribution of neuropeptide Y Y 1 , Y 2 , Y 4 , and Y 5 receptor subtypes was investigated in rodents (rat and mouse), guinea pig, and primates (marmoset and vervet monkeys and human) brains, representing three orders of mammals. [ 125 I][Leu 31 ,Pro 34 ]PYY (total Y 1 -like; Y 1 , Y
## Abstract Central administration of neuropeptide Y (NPY) causes both anxiolysis and sedation. Previous studies suggest that both effects are mediated via NPY Y1 receptors. However, most of these studies were carried out before the advent of specific NPY receptor ligands. Therefore, a potential ro