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Agonist stimulation of B1 and B2 kinin receptors causes activation of the MAP kinase signaling pathway, resulting in the translocation of AP-1 in HEK 293 cells

โœ Scribed by Hiroaki Naraba; Akinori Ueno; Yae Kosugi; Mineka Yoshimura; Makoto Murakami; Ichiro Kudo; Sachiko Oh-ishi

Book ID
117109688
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
274 KB
Volume
435
Category
Article
ISSN
0014-5793

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon