a-BgTx, EPI or IMI. In contrast the dissociation rate was markedly increased when initiated by MLA compared to a-BgTx, EPI or IMI (Fig 1). Displacement of [ 125 I]a-BgTx, [ 3 H]EPI and [ 3 H]IMI by MLA was with high potency with an IC 50 value close to the K d value of each of these labelled ligand
Agonist self-inhibitory binding site of the nicotinic acetylcholine receptor
✍ Scribed by H.R. Arias
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 1020 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0360-4012
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Mouse strains are well‐characterized to exhibit differences in their physiological and behavioral responses to nicotine. This report examines the expression of the high‐affinity nicotine binding receptor subunit, neuronal nicotinic receptor subunit alpha4 (nAChRα4), in the dorsal hippoc
## Abstract The lead compound of a new series of azabicyclic carbamates described by Astra Laboratories as ligands for the __α__7 nicotinic acetylcholine receptor subtype, namely __N__‐(4‐bromophenyl)carbamic acid quinuclidin‐3‐yl ester, has been labelled with carbon‐11 using no‐carrier‐added [^11^
## Abstract A group of agonists for the α7 neuronal nicotinic acetylcholine receptors (nAChRs) was investigated, and their free energies of binding Δ__G__~bind~ were calculated by applying the molecular mechanics Poisson–Boltzmann surface area (MM‐PBSA) approach. This method, based on molecular dyn