Agmatine prevents the Ca2+-dependent induction of permeability transition in rat brain mitochondria
β Scribed by V. Battaglia; S. Grancara; J. Satriano; S. Saccoccio; E. Agostinelli; A. Toninello
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 285 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0939-4451
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## Abstract The role of regucalcin, which is a regulatory protein in intracellular signaling, in the regulation of Ca^2+^βATPase activity in the mitochondria of brain tissues was investigated. The addition of regucalcin (10^β10^ to 10^β8^ M), which is a physiologic concentration in rat brain tissue
Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc