Modulation of the Permeability Transition Pore by Inhibition of the Mitochondrial KATPChannel in Livervs. Brain Mitochondria
โ Scribed by K. Kupsch; S. Parvez; D. Siemen; G. Wolf
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 240 KB
- Volume
- 215
- Category
- Article
- ISSN
- 0022-2631
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Mitochondria of higher cells contain a channel, the permeability transition pore (PTP), that, when open, increases the permeability of the inner membrane to ions and small molecules. The PTP may be of importance in cellular calcium homeostasis and in the execution of programmed cell death, and the d
## Abstract The pathological consequences of traumatic head injury result largely from the opening of the mitochondrial permeability transition pore (mPTP). The mPTP opens due to a decrease in brain phosphorylation energy resulting in a further decrease in brain ATP production and a measurable incr