The abundance of mitochondrial DNA (mtDNA) deletions has been shown to increase with age in a number of species and may contribute to the aging process. Estimating the total mtDNA deletion load of an individual is essential in evaluating the potential physiological impact. In this study, we compared
Aging of the liver: Age-associated mitochondrial damage in intact hepatocytes
✍ Scribed by J Sastre; F V Pallardó; R Plá; A Pellín; G Juan; J E O'Connor; J M Estrela; J Miquel; J Viña
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 861 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
NADH, reduced nicotinamide adenine dinucleotide; NAD / , oxidized nicotinamide adenine per milliliter) were incubated in Krebs-Henseleit bicarbonate buffer.
dinucleotide.
From the Departamento de 1 FisiologıB a, 2 PatologıB a, and 3 BioquıB mica y BiologıB a Molecular,
The gas atmosphere was O 2 /CO 2 (19:1). Incubation time was 30 min-
📜 SIMILAR VOLUMES
## Abstract Increasing evidence supports the notion that increased oxidative stress is a fundamental cause in the aging process and in neurodegenerative diseases. As a result, a decline in cognitive function is generally associated with brain aging. Reactive oxygen species (ROS) are highly reactive
Muscle performance and the energy derived from adenosine triphosphate (ATP) are closely linked. ATP is both indispensable to muscle contraction and produced almost exclusively by mitochondria. The susceptibility of muscle and other postmitotic tissues to impairments of oxidative phosphorylation has
Several biochemical, physiological, and behavioral processes exhibit cyclic oscillations of about 24 h, which have been defined as circadian rhythms. In mammals, the primary circadian pacemaker resides in the suprachiasmatic nuclei; however, cell-autonomous circadian oscillators occur also in extran
We showed previously that a mutation in the mitochondria1 tRNAL"(UUR' gene at position 3243 associates with maternally inherited diabetes and deafness (MIDD). This mutation shows heteroplasmy in DNA from peripheral blood and other tissues. To examine whether heteroplasmy levels in peripheral blood D