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Mitochondrial myopathy in the elderly: Exaggerated aging in the pathogenesis of disease

✍ Scribed by Jerry R. Mendell

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
221 KB
Volume
37
Category
Article
ISSN
0364-5134

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✦ Synopsis

Muscle performance and the energy derived from adenosine triphosphate (ATP) are closely linked. ATP is both indispensable to muscle contraction and produced almost exclusively by mitochondria. The susceptibility of muscle and other postmitotic tissues to impairments of oxidative phosphorylation has been well recognized and emphasized in careful descriptions of the mitochondrial encephalomyopathies, including Kearns-Sayre syndrome, myoclonic epilepsy and ragged red fibers ( M E W ) , mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), and Leigh syndrome [l].

Recently, the potential importance of the mitochon-

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