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Aging, Drugs, and Drug Metabolism

✍ Scribed by Le Couteur, D. G.; McLachlan, A. J.; de Cabo, R.


Book ID
118235430
Publisher
The Gerontological Society of America
Year
2011
Tongue
English
Weight
84 KB
Volume
67A
Category
Article
ISSN
1079-5006

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The clearance of many drugs by the liver is reduced in the elderly, and this accounts, at least in part, for the greater frequency of adverse drug reactions in this population. Ageing in experimental animals is accompanied by a decline in the activities of certain microsomal monooxygenase enzymes;