Ageing and metabolism: drug discovery opportunities
β Scribed by Curtis, Rory; Geesaman, Bard J.; DiStefano, Peter S.
- Book ID
- 109949808
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 553 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1474-1776
- DOI
- 10.1038/nrd1777
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Cell suicide is a normal process that participates in a wide variety of physiological processes, including tissue homeostasis, immune regulation, and fertility. Physiological cell death typically occurs by apoptosis, as opposed to necrosis. Defects in apoptotic cell-death regulation contribute to ma
## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t
The need for high-throughput approaches in absorption, distribution, metabolism and excretion studies is driven by the impact of high-speed chemistry and pharmacological screening. Perhaps an even greater impact is that these studies will, in the future, provide large data sets that can be used to p