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Aggressive skin allograft rejection in CD28−/− mice independent of the CD40/CD40L costimulatory pathway

✍ Scribed by Jongwon Ha; Adam W Bingaman; Megan M Durham; Thomas C Pearson; Christian P Larsen


Book ID
117676252
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
110 KB
Volume
9
Category
Article
ISSN
0966-3274

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The CD40 pathway in allograft rejection,
✍ Christian P Larsen; Thomas C Pearson 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 713 KB

The CD40 pathway plays a critical role at many levels of the sensitization and effector phases of allograft rejection. In addition to the important signaling role of this pathway for T cell help and effector function, recent evidence suggests that the CD40 pathway can directly co-stimulate T cells,