✦ LIBER ✦

The CD40 pathway in allograft rejection, acceptance, and tolerance

✍ Scribed by Christian P Larsen; Thomas C Pearson

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 713 KB
Volume: 9
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(97)80043-x

No coin nor oath required. For personal study only.

✦ Synopsis

The CD40 pathway plays a critical role at many levels of the sensitization and effector phases of allograft rejection. In addition to the important signaling role of this pathway for T cell help and effector function, recent evidence suggests that the CD40 pathway can directly co-stimulate T cells, independently of its effect on the B7-CD28 pathway.

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