Freeze-thawing is a potentially damaging stress to which therapeutic proteins can be exposed deliberately during storage of bulk drug substance, and accidentally because of mishandling of commercial product during shipping and/or storage. The primary route of degradation induced by freeze-thawing is
Aggregation Stability of a Monoclonal Antibody During Downstream Processing
✍ Scribed by Paolo Arosio; Giuliano Barolo; Thomas Müller-Späth; Hua Wu; Massimo Morbidelli
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 614 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0724-8741
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