✦ LIBER ✦

Evaluation of a non-arrhenius model for therapeutic monoclonal antibody aggregation

✍ Scribed by Veysel Kayser; Naresh Chennamsetty; Vladimir Voynov; Bernhard Helk; Kurt Forrer; Bernhardt L. Trout

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 720 KB
Volume: 100
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.22493

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

A high-resolution capillary isoelectric

A high-resolution capillary isoelectric focusing method for the determination of therapeutic recombinant monoclonal antibody

✍ Jun Lin; Qingqiao Tan; Shaoxiong Wang 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB

## Abstract Capillary isoelectric focusing (CIEF) is a common choice for separation and analysis of the charge variants and impurities of therapeutic proteins. In this study, we developed a sensitive CIEF analysis method for determining the charge heterogeneity of therapeutic monoclonal antibody (m

Use of a folding model and in situ spect

Use of a folding model and in situ spectroscopic techniques for rational formulation development and stability testing of monoclonal antibody therapeutics

✍ Gauri Rao; Vandana Iyer; Matthew P. Kosloski; Dipak S. Pisal; Eunkyoung Shin; C. 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 260 KB 👁 1 views

Aggregation is a critical issue that hampers the development of monoclonal antibody therapeutics (Mabs). Traditionally, aggregation is considered a process in which native forms of proteins are transformed into an unstable highly associated form through an intermediate formation step. Here we descri

Process and economic evaluation for mono

Process and economic evaluation for monoclonal antibody purification using a membrane-only process

✍ Hemanthram Varadaraju; Steven Schneiderman; Lifeng Zhang; Hao Fong; Todd J. Menk 📂 Article 📅 2011 🏛 American Institute of Chemical Engineers 🌐 English ⚖ 590 KB

Comparative evaluation of disodium edeta

Comparative evaluation of disodium edetate and diethylenetriaminepentaacetic acid as iron chelators to prevent metal-catalyzed destabilization of a therapeutic monoclonal antibody

✍ Shuxia Zhou; Bo Zhang; Emily Sturm; Dirk L. Teagarden; Christian Schöneich; Para 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English

Understanding the effect of metal chelators with respect to their ability to inhibit metal-catalyzed degradation in biologic products is a critical component for solution formulation development. Two metal chelators, disodium edetate (Na(2)EDTA) and diethylenetriaminepentaacetic acid (DTPA), were ev

Monoclonal antibodies to placental alkal

Monoclonal antibodies to placental alkaline phosphatase: Preclinical evaluation in a human xenograft tumour model of F(ab')2 and Fab fragments

✍ H. Durbin; E. M. Milligan; S. J. Mather; D. F. Tucker; R. Raymond; W. F. Bodmer 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 531 KB

Six new placental alkaline phosphatase monoclonal antibodies (MAbs) have been evaluated in order to select a potentially clinically useful antibody fragment for use in immunoxintigraphy or therapy. Initially, 3 antibodies were identified by trial pepsin digestion as likely to give satisfactory F(ab'

The hepatitis B virus–trimera mouse: A m

The hepatitis B virus–trimera mouse: A model for human HBV infection and evaluation of anti-HBV therapeutic agents

✍ Ehud Ilan; Tatjana Burakova; Shlomo Dagan; Ofer Nussbaum; Ido Lubin; Rachel Eren 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 459 KB 👁 2 views

Previous studies have demonstrated the feasibility of implantation of human blood cells or tissues in lethally irradiated mice or rats, radioprotected with SCID mouse bone marrow cells: The Trimera system. In the present study, we describe the development of a mouse Trimera model for human hepatitis