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Aggregation of the Amphipathic Peptides (AAKA) n into Antiparallel β-Sheets

✍ Scribed by Measey, Thomas J.; Schweitzer-Stenner, Reinhard


Book ID
126197382
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
88 KB
Volume
128
Category
Article
ISSN
0002-7863

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A 20-membered cyclic peptide disulfide Boc-C ys-Val-Aib-Ma-Leu-C ys-NHMe I I S S has been synthesized as a conformational model for disulfide loops of limited ring size. 'H-nmr studies at 270 MHz establish the presence of three intramolecular hydrogen bonds involving the Leu, Val, and methylamide NH