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β-Sheet Peptide Architecture: Measuring the Relative Stability of Parallel vs. Antiparallel β-Sheets

✍ Scribed by Dr. Kenji Kobayashi; Dr. Juan R. Granja; Prof. M. Reza Ghadiri


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
794 KB
Volume
34
Category
Article
ISSN
0044-8249

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A 20-membered cyclic peptide disulfide Boc-C ys-Val-Aib-Ma-Leu-C ys-NHMe I I S S has been synthesized as a conformational model for disulfide loops of limited ring size. 'H-nmr studies at 270 MHz establish the presence of three intramolecular hydrogen bonds involving the Leu, Val, and methylamide NH