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Aggregation of cyclodextrins: An explanation of the abnormal solubility ofβ-cyclodextrin

✍ Scribed by Anthony W. Coleman; Ioannis Nicolis; Nelly Keller; Jean Pierre Dalbiez


Publisher
Springer Netherlands
Year
1992
Tongue
English
Weight
260 KB
Volume
13
Category
Article
ISSN
0923-0750

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Inhibition of agitation-induced aggregat
✍ Tim Serno; John F. Carpenter; Theodore W. Randolph; Gerhard Winter 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 280 KB

In order to provide an alternative to nonionic surfactants as excipients for protein formulations, cyclodextrin-derivatives (CDs) were examined for their potential to inhibit agitation-induced aggregation of an IgG in aqueous solution. Loss of monomeric protein and protein aggregation were monitored