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Photostability and solubility improvement of β-cyclodextrin-included tretinoin

✍ Scribed by Carla Caddeo; Maria Manconi; Donatella Valenti; Elena Pini; Chiara Sinico

Publisher
Springer Netherlands
Year
2007
Tongue
English
Weight
320 KB
Volume
59
Category
Article
ISSN
0923-0750

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Acitretin, a retinoid for the treatment of severe psoriasis, exhibits extremely low aqueous solubility and high photosensitivity. This study investigated the effects of the complexation of acitretin with the respective hydroxypropyl-beta-cyclodextrin (HPBCD) and randomly substituted methyl-beta-cycl