Aggregation of a Lyophilized Pharmaceutical Protein, Recombinant Human Albumin: Effect of Moisture and Stabilization by Excipients
โ Scribed by Costantino, Henry R. ;Langer, Robert ;Klibanov, Alexander M.
- Book ID
- 109903516
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 494 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1087-0156
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We have investigated the effect of mannitol, sorbitol, methyl R-D-mannopyranoside, lactose, trehalose, and cellobiose on the stability and structure of the pharmaceutical protein recombinant human growth hormone (rhGH) in the lyophilized state. All excipients afforded significant protection of the p
The objective was to evaluate the impact of pH and NaCl content on aggregation, particle formation, and solubility of a hydrophobic recombinant human cytokine in formulations with human serum albumin (HSA) as stabilizing excipient. While cytokine-HSA formulations were stable at physiological pH, a t